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[Biotransformation of pyridazines. 1. Pyridazine and 3-methylpyridazine]
H H Borchert1, S Pfeifer, B Helbig
1Sektion Chemie, Wissenschaftsbereich Pharmazie, Humboldt-Universität zu Berlin.
Die Pharmazie
|September 1, 1989
Abstract:
Pyridazin (1) and 3-methylpyridazine (6) undergo oxidative biotransformation in an unexpected high degree. Beside the unchanged compounds, after administration of 1 two isomeric monohydroxylated products (2, 3), 4,5-dihydrodihydroxypyridazine (4) and 4,5-dihydroxypyridazine (5) and after administration of 6 one ringhydroxylated 6-derivative (7), 3-hydroxymethylpyridazine (8), one ringhydroxylated 3-hydroxymethylpyridazine derivative (9) and 4,5-dihydroxy-3-methylpyridazine (10) were suggested as urinary metabolites in rats. 2 and 7 are the main metabolites of 1 and 6, respectively.