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Effect of ciclosporin on rat liver and kidney glutathione content
V A Duruibe1, A Okonmah, G T Blyden
1Clinical Pharmacology Research Unit, College of Pharmacy, Florida Agricultural and Mechanical University, Miami.
Abstract:
The effect of ciclosporin (CS) on hepatic and renal glutathione was investigated in 36 male Sprague-Dawley rats weighing 200-250 g each. CS (120 micrograms/kg/day, i.p.) treatment caused a significant decrease in both hepatic and renal glutathione content. The rat hepatic glutathione levels decreased by 16% within 1 h of a single CS treatment and continued decreasing to 50% following chronic treatment with CS for 7 days. Renal glutathione content decreased only marginally (3%) within 1 h of CS treatment. However, it decreased by 17% within 24 h and continued to decrease during the 7 days of chronic treatment. This decrease in the content of both hepatic and renal glutathione may contribute to the toxicity observed during treatment with CS.
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