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Related Experiment Video

Updated: Apr 9, 2026

Differentiation of Human Pluripotent Stem Cells into Insulin-Producing Islet Clusters

Differentiation of Human Pluripotent Stem Cells into Insulin-Producing Islet Clusters

Published on: June 23, 2023

Pancreatic islet cell development and regeneration.

Anthony I Romer¹, Lori Sussel

¹Department of Genetics and Development, Columbia University, New York, New York, USA.

Current Opinion in Endocrinology, Diabetes, and Obesity

|June 19, 2015

Summary

Recent research shows that adult islet cells can change types and that stem cells can become beta cells. These findings offer new ways to replenish beta cells for diabetes treatment.

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Generation of Scaffold-free, Three-dimensional Insulin Expressing Pancreatoids from Mouse Pancreatic Progenitors In Vitro

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Generation of Scaffold-free, Three-dimensional Insulin Expressing Pancreatoids from Mouse Pancreatic Progenitors In Vitro

Generation of Scaffold-free, Three-dimensional Insulin Expressing Pancreatoids from Mouse Pancreatic Progenitors In Vitro

Published on: June 2, 2018

Area of Science:

Endocrinology
Developmental Biology
Regenerative Medicine

Background:

Pancreatic islet development and function are crucial for glucose homeostasis.
Understanding beta cell biology is key to treating diabetes mellitus.

Purpose of the Study:

Review recent advances in pancreatic islet cell development.
Discuss novel concepts in beta cell dysfunction.
Explore improved strategies for beta cell replenishment in diabetes.

Main Methods:

Review of current literature on pancreatic islet development in mouse and human models.
Analysis of studies on beta cell plasticity and conversion.
Evaluation of stem cell-derived beta-like cell generation techniques.

Main Results:

Differentiated adult islet cells exhibit plasticity, convertible to other cell types via transcription factor manipulation.
Significant progress in generating functional beta-like cells from stem cell populations.
In-situ conversion and directed differentiation offer novel pathways for beta cell regeneration.

Conclusions:

Conservation between mouse and human pancreatic development supports translation of therapies.
Further research into molecular mechanisms of islet cell regeneration and plasticity can enhance diabetes treatments.
Novel beta cell replacement strategies hold promise for managing diabetes.