Related Experiment Video
Updated: Apr 9, 2026
05:52
Early Pathological and Magnetic Resonance Detection of Cerebral Injury Using a Rat Model of Neonatal Hypoxic Ischemic Encephalopathy
Published on: October 28, 2022
1.1K
Infantile Tubercular Meningitis With Brain Infarct
Panagiotis Kratimenos1, Ioannis Koutroulis, Mike Fruscione
1From the *Department of Pediatrics, Drexel University College of Medicine, and St. Christopher's Hospital for Children, Philadelphia, PA; and †Department of Pediatrics, Drexel University College of Medicine, The Unterberg Children's Hospital at Monmouth Medical Center, Long Branch, NJ.
Pediatric Emergency Care
|June 19, 2015
Summary
Tuberculosis can affect infants, causing serious neurological complications like meningitis and hydrocephalus. Early diagnosis and treatment are crucial for managing this severe pediatric infection.
Area of Science:
- Pediatrics
- Neurology
- Infectious Diseases
Background:
- Tuberculosis (TB) is a significant global health concern, particularly in developing regions.
- While TB primarily affects the lungs, it can manifest in extrapulmonary sites, including the central nervous system.
Observation:
- A 6-month-old infant presented with symptoms initially suggestive of pneumonia, followed by neurological deficits including facial asymmetry and limb weakness.
- The patient's mother and grandmother had a history of chronic cough, with the mother's chest radiograph showing signs consistent with pulmonary tuberculosis.
Findings:
- Cerebrospinal fluid analysis and clinical presentation strongly indicated tuberculous meningitis.
- Magnetic resonance imaging revealed findings consistent with a cerebrovascular event.
- Despite a 4-drug antituberculosis regimen and dexamethasone, the patient developed obstructive hydrocephalus.
Implications:
- This case highlights the importance of considering tuberculous meningitis in infants presenting with neurological symptoms, especially with a relevant family history of tuberculosis.
- Prompt diagnosis and comprehensive treatment are essential to prevent severe neurological sequelae such as hydrocephalus.
- Further research into the long-term neurological outcomes and management strategies for pediatric tuberculous meningitis is warranted.
Related Concept Videos
01:28Pulmonary Tuberculosis II
2.2K
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
2.2K
01:18Viral Meningitis
133
Viral meningitis is the most common form of meningitis and is often referred to as aseptic meningitis to indicate the absence of bacterial involvement. It is generally milder than bacterial meningitis, with symptoms including fever, headache, stiff neck, drowsiness, nausea, photophobia, and vomiting. Rarely, more severe manifestations or death may occur. Common causative agents include enteroviruses, particularly coxsackie A and B viruses and echoviruses, all members of the Enterovirus genus...
133
01:26Pulmonary Tuberculosis IV
741
Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
741
01:31Pulmonary Tuberculosis III
1.5K
Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
The first classification is based on the development of the disease, and it includes the following categories:
1.5K
01:29Pulmonary Tuberculosis I
1.5K
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
1.5K