[Tumor volume as a predictive factor in a group of children with poor-prognosis Hodgkin's lymphoma ]

The aim of this study is an attempt to highlight in the group of patients with a poor prognosis the cohort of patients who need to be planned escalation of doses of cytostatics and transplantation of donor cells. The analysis includes data on 126 patients with Hodgkin's lymphoma at the age from 2 to 18 years (mean age 11 years). All children were treated by risk adapted programs (DAL-HD-like and SPbLH-05). Into the group with a favorable prognosis there were stratified 58 patients (46%), with an intermediate prognosis--50 (39.7%) and with a poor prognosis--18 patients (14.3%). Isolation of patients with relative volume of tumor lesion exceeding 345cm3/m2 requires an intensification of treatment program and an introduction of risk adapted therapy with planning of high-dose treatment.