Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Methods of Nuclear Reprogramming01:24

Methods of Nuclear Reprogramming

2.3K
Nuclear reprogramming is a process of transforming one cell type into an unrelated cell type by epigenetic changes that alter the cell’s original gene expression pattern. Such epigenetic changes force cells to express a different set of genes, which play a significant role in inducing transformation into other cell types. Nuclear reprogramming offers applications in reproductive cloning for livestock propagation and regenerative medicine — developing patient-specific cells for...
2.3K
Somatic to iPS Cell Reprogramming01:29

Somatic to iPS Cell Reprogramming

2.9K
Reprogramming alters the gene expression in somatic cells, transforming them into induced pluripotent stem (iPS) cells over several generations. Scientists can reprogram cells by introducing genes for four transcription factors—Oct4, Sox2, Klf4, and c-Myc (OSKM) by viral or non-viral methods. These factors are also known as Yamanaka factors after Shinya Yamanaka, who first generated iPS cells using mouse skin cells. Yamanaka was awarded the Nobel Prize in Physiology or Medicine in 2012...
2.9K
Introduction to Nuclear Reprogramming01:14

Introduction to Nuclear Reprogramming

2.4K
Nuclear reprogramming is the process of switching gene expression of one cell type to that of another cell type, usually from a differentiated cell state to an undifferentiated cell state. Differentiation occurs during processes such as development and morphogenesis, tissue regeneration, and malignancy. Cells can also be artificially induced to reprogram their gene expression by techniques such as nuclear transfer, induced pluripotency, and cell fusion. Such techniques have many applications in...
2.4K
Chromatin Modification in iPS Cells01:32

Chromatin Modification in iPS Cells

2.3K
Chromatin modification alters gene expression; therefore, scientists can add histone-modifying enzymes, histone variants, and chromatin remodeling complexes to somatic cells to aid reprogramming into pluripotent stem (iPS) cells.
Compact chromatin makes reprogramming difficult. Enzymes, such as histone demethylases and acetyltransferases, are often added during reprogramming to loosen the chromatin, making the DNA more accessible to transcription factors. Molecules that inhibit histone...
2.3K
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

4.1K
4.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Generation of the RCPCMi014-A and RCPCMi014-B lines from T-lymphocytes of a healthy donor and verification of their monoclonal origin by TCR V(D)J rearrangement analysis.

Vavilovskii zhurnal genetiki i selektsii·2026
Same author

Changes in potential pathogenicity-associated proteins of <i>Helicobacter cinaedi</i> upon infection of macrophage cells.

Frontiers in microbiology·2025
Same author

Changes of α-Synuclein Localization in a Neuronal Precursor Graft in the Rat Model of 6-OHDA-Induced Parkinsonism.

Bulletin of experimental biology and medicine·2025
Same author

[Factors of delayed gastric emptying after pancreaticoduodenectomy].

Khirurgiia·2025
Same author

Generation of CRISPR/Cas9 modified human iPSC line with correction of heterozygous mutation in exon 6 of the CaSR gene.

Human cell·2024
Same author

[Changes of a₂-macroglobulin activity and endothelin-1 concentration in tears of rabbits after transplantation of retinal pigment epithelium cells derived from the induced pluripotent stem cells].

Biomeditsinskaia khimiia·2022

Related Experiment Video

Updated: Apr 9, 2026

Isolation of Adult Human Dermal Fibroblasts from Abdominal Skin and Generation of Induced Pluripotent Stem Cells Using a Non-Integrating Method
10:52

Isolation of Adult Human Dermal Fibroblasts from Abdominal Skin and Generation of Induced Pluripotent Stem Cells Using a Non-Integrating Method

Published on: January 19, 2020

11.6K

[Genetic Cell Reprogramming: A New Technology for Basic Research and Applied Usage].

A N Bogomazova, E M Vassina, S I Kiselev

    Genetika
    |June 20, 2015
    PubMed
    Summary

    Scientists can reprogram adult cells into induced pluripotent stem cells (iPSCs), which mimic embryonic stem cells. This breakthrough offers new avenues for studying development and disease, advancing regenerative medicine.

    More Related Videos

    RNA-based Reprogramming of Human Primary Fibroblasts into Induced Pluripotent Stem Cells
    11:38

    RNA-based Reprogramming of Human Primary Fibroblasts into Induced Pluripotent Stem Cells

    Published on: November 26, 2018

    11.2K
    Selecting and Isolating Colonies of Human Induced Pluripotent Stem Cells Reprogrammed from Adult Fibroblasts
    13:23

    Selecting and Isolating Colonies of Human Induced Pluripotent Stem Cells Reprogrammed from Adult Fibroblasts

    Published on: February 20, 2012

    20.5K

    Related Experiment Videos

    Last Updated: Apr 9, 2026

    Isolation of Adult Human Dermal Fibroblasts from Abdominal Skin and Generation of Induced Pluripotent Stem Cells Using a Non-Integrating Method
    10:52

    Isolation of Adult Human Dermal Fibroblasts from Abdominal Skin and Generation of Induced Pluripotent Stem Cells Using a Non-Integrating Method

    Published on: January 19, 2020

    11.6K
    RNA-based Reprogramming of Human Primary Fibroblasts into Induced Pluripotent Stem Cells
    11:38

    RNA-based Reprogramming of Human Primary Fibroblasts into Induced Pluripotent Stem Cells

    Published on: November 26, 2018

    11.2K
    Selecting and Isolating Colonies of Human Induced Pluripotent Stem Cells Reprogrammed from Adult Fibroblasts
    13:23

    Selecting and Isolating Colonies of Human Induced Pluripotent Stem Cells Reprogrammed from Adult Fibroblasts

    Published on: February 20, 2012

    20.5K

    Area of Science:

    • Stem cell biology
    • Developmental biology
    • Genetic engineering

    Context:

    • Modern genetic manipulation technologies enable cell reprogramming.
    • Adult somatic cells can be reverted to an embryonic-like pluripotent state.

    Purpose:

    • To review the fundamental and applied aspects of induced pluripotent stem cells (iPSCs).
    • To highlight the potential of iPSCs in developmental biology and disease modeling.

    Summary:

    • Induced pluripotent stem cells (iPSCs) are generated by reprogramming adult cells using specific transcription factors.
    • iPSCs possess pluripotency, enabling them to differentiate into various cell types and model developmental stages.
    • These cells can be maintained in culture, allowing for genetic manipulation and long-term study.

    Impact:

    • iPSCs provide novel tools for understanding basic developmental mechanisms and cell differentiation.
    • They offer significant potential for disease pathology studies and the development of therapeutic strategies.
    • The ability to genetically manipulate iPSCs enhances their utility in regenerative medicine research.