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Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

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The relationship between weight, height and body mass index with hemodynamic parameters is not same in patients with

Baris Afsar1, Rengin Elsurer2, Zeki Soypacaci3

  • 1Department of Nephrology, Ferhuniye Mah. Hastane Cad. Konya Numune State Hospital, 42690, Konya, Turkey. afsarbrs@yahoo.com.

Clinical and Experimental Nephrology
|June 20, 2015
PubMed

Insights

In patients with chronic kidney disease (CKD), higher weight and body mass index (BMI) are linked to decreased arterial stiffness. This contrasts with non-CKD patients, where these factors increase stiffness.

Area of Science:

  • Cardiology
  • Nephrology
  • Clinical Physiology

Background:

  • Anthropometric measurements correlate with clinical outcomes, but this relationship varies in specific conditions like chronic kidney disease (CKD).
  • Understanding these variations is crucial for managing cardiovascular health in CKD patients.

Purpose of the Study:

  • To investigate the relationship between height, weight, and body mass index (BMI) with hemodynamic and arterial stiffness parameters.
  • To compare these relationships separately in patients with and without CKD.

Main Methods:

  • A cross-sectional study involving 381 hypertensive patients (226 with CKD, 155 without).
  • Measurements included routine labs, 24-h urine collection, augmentation index (Aix@75), and pulse wave velocity (PWV) using the mobil-O-Graph device.

Main Results:

  • In non-CKD patients, height correlated inversely with Aix@75; weight and BMI positively associated with PWV.
  • In CKD patients, weight and BMI showed an inverse relationship with PWV, indicating decreased arterial stiffness with increasing weight/BMI.
  • The association between BMI, weight, and arterial stiffness was positive in normal individuals but negative in CKD patients.

Conclusions:

  • The relationship between anthropometric measurements (height, weight, BMI) and hemodynamic/arterial stiffness parameters is significantly different in patients with and without CKD.
  • These findings highlight the complex interplay between body composition and cardiovascular health in the context of kidney disease.
Abstract

Keywords:
Body mass indexChronic kidney diseaseHeightHemodynamicHypertensionStiffnessWeight

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