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Atherosclerosis I: Introduction01:30

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Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
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Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
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Quantification of Atherosclerosis in Mice
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[Epigenetics in atherosclerosis].

Montse Guardiola1, Joan C Vallvé1, Silvio Zaina2

  • 1Unitat de Recerca de Lípids i Arteriosclerosi, Facultat de Medicina, Universitat Rovira i Virgili, Reus, España.

Clinica E Investigacion En Arteriosclerosis : Publicacion Oficial De La Sociedad Espanola De Arteriosclerosis
|June 20, 2015
PubMed
Summary
This summary is machine-generated.

Epigenetics, the study of gene regulation without DNA sequence changes, is key to understanding individual atherosclerosis risk. Environmental factors significantly influence this complex disease, making epigenetics crucial for future research.

Keywords:
ADNArteriosclerosisAtherosclerosisDNAEpigeneticsEpigenéticaHistonasHistonesMethylationMetilaciónmicro ARNmicro RNA

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Area of Science:

  • Cardiovascular Science
  • Genetics
  • Epigenetics

Background:

  • Decades of genetic association studies have illuminated the genetic basis of complex diseases like atherosclerosis.
  • Despite progress, individual predisposition to atherosclerosis remains incompletely understood, particularly the interplay between genes and environment.
  • Environmental factors significantly impact atherosclerosis development and progression.

Purpose of the Study:

  • To define epigenetics and its core mechanisms.
  • To elucidate the role of epigenetic mechanisms in the development and progression of atherosclerosis.
  • To highlight epigenetics as a critical area for expanding knowledge on individual cardiovascular disease risk.

Main Methods:

  • This review synthesizes current knowledge on epigenetics.
  • It focuses on epigenetic mechanisms relevant to transcriptional regulation.
  • The review examines how these mechanisms are implicated in atherosclerosis.

Main Results:

  • Epigenetics provides a framework for understanding environmentally induced gene expression changes.
  • Specific epigenetic modifications are increasingly linked to atherosclerosis pathogenesis.
  • Epigenetic alterations offer potential biomarkers and therapeutic targets for cardiovascular disease.

Conclusions:

  • Epigenetics is pivotal for deciphering individual susceptibility to atherosclerosis.
  • Understanding epigenetic regulation is essential for advancing cardiovascular disease research.
  • Further investigation into epigenetic mechanisms will enhance personalized medicine approaches for atherosclerosis.