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Assessing Cellular Target Engagement by SHP2 PTPN11 Phosphatase Inhibitors
08:45

Assessing Cellular Target Engagement by SHP2 PTPN11 Phosphatase Inhibitors

Published on: July 17, 2020

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Functions of Shp2 in cancer

Jie Zhang1, Fei Zhang1, Ruifang Niu1

  • 1Key Laboratory of Breast Cancer Prevention and Therapy, Ministry of Education, Key Laboratory of Cancer Prevention and Therapy, National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.

Journal of Cellular and Molecular Medicine
|June 20, 2015
PubMed

Insights

Src homology region 2-containing protein tyrosine phosphatase 2 (Shp2) is crucial in various cancers. Research explores Shp2 as a therapeutic target, but conflicting findings require further investigation for effective cancer treatment strategies.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Cancer diagnostics and therapies have advanced, yet intracellular mechanisms remain elusive.
  • Src homology region 2-containing protein tyrosine phosphatase 2 (Shp2) is implicated in multiple cancer types, including breast, lung, and liver cancers.
  • Shp2's role extends to developmental disorders like Noonan syndrome when its encoding gene, PTPN11, mutates.

Purpose of the Study:

  • To investigate the molecular mechanisms of Shp2 in cancer.
  • To evaluate Shp2 as a potential therapeutic target for cancer treatment.
  • To review the existing literature on Shp2's function in cancer and identify areas of conflict.

Main Methods:

  • Literature review of studies investigating Shp2's role in cancer.
  • Analysis of Shp2's involvement in cancer-related processes such as invasion, metastasis, apoptosis, and drug resistance.
  • Examination of Shp2 inhibitors in experimental cancer treatment strategies.

Main Results:

  • Shp2 is associated with key cancer processes including cell proliferation, cell cycle regulation, DNA damage, and drug resistance.
  • Shp2 signaling pathways are increasingly understood in the context of various malignancies.
  • Shp2 inhibitors have shown promise in preclinical studies, indicating therapeutic potential.

Conclusions:

  • Shp2 represents a significant potential therapeutic target in oncology due to its multifaceted roles in cancer progression.
  • Further research is necessary to resolve conflicting results regarding Shp2's functions and optimize targeted therapies.
  • Understanding Shp2's precise mechanisms is critical for developing effective and specific cancer treatments.
Keywords:
DNA damageShp2apoptosiscancercell proliferationdrug resistanceinvasion and metastasis

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