Association between osteocalcin and glucose metabolism: a meta-analysis
Summary
Osteocalcin (Ocn) and its undercarboxylated form (unOcn) are negatively associated with fasting plasma glucose (FPG) and glycated hemoglobin A1c (HbA1c). These glucose metabolism correlations are stronger in men than in women.
Area of Science:
- Endocrinology
- Metabolic Health
- Biomarkers
Background:
- Osteocalcin (Ocn) is a bone-derived hormone influencing glucose metabolism.
- Understanding the relationship between Ocn and glycemic control is crucial for metabolic health research.
Purpose of the Study:
- To conduct a meta-analysis investigating the associations between osteocalcin (total Ocn and undercarboxylated Ocn) and key glycemic markers: fasting plasma glucose (FPG) and glycated hemoglobin A1c (HbA1c).
- To explore potential sex differences in these associations.
Main Methods:
- A systematic literature search was performed across PubMed, ISI Web of Science, and Cochrane Library databases (2007-2014).
- Meta-analysis techniques were employed to derive pooled effect sizes and 95% confidence intervals (CI).
Main Results:
- The meta-analysis included 39 studies with 23,381 participants.
- Both total Ocn and undercarboxylated Ocn (unOcn) showed significant negative correlations with FPG and HbA1c.
- The negative association between unOcn and FPG was significantly more pronounced in men compared to women.
Conclusions:
- Osteocalcin, in both total and undercarboxylated forms, is negatively correlated with markers of glucose metabolism (FPG and HbA1c) in humans.
- The impact of unOcn on glucose metabolism appears to be greater in men than in women.
Related Concept Videos
01:16Hormones Regulating Blood Glucose
8.8K
Insulin is released by beta cells of the pancreas when blood glucose levels are high. It facilitates glucose absorption and utilization in insulin-dependent cells with insulin receptors on their plasma membranes. Insulin promotes glucose uptake by increasing the number of glucose transport proteins in the cell membrane, allowing glucose to enter the cell. As a result, glucose utilization and ATP production are enhanced.
In addition to accelerating glucose uptake and utilization, insulin has...
In addition to accelerating glucose uptake and utilization, insulin has...
8.8K
01:02Glucose Homeostasis: Regulation of Blood Glucose
5.4K
Carbohydrates consumed through foods are converted into glucose, a crucial energy source for the body. In the prandial state, high blood glucose levels stimulate the secretion of insulin from the pancreas. Insulin inhibits hepatic glucose production and stimulates glucose uptake and metabolism by muscle and adipose tissue. The excess glucose is converted into glycogen and stored in the liver and muscles.
During fasting, when blood glucose levels are low, the pancreas secretes glucagon. it...
During fasting, when blood glucose levels are low, the pancreas secretes glucagon. it...
5.4K
01:27Glucose Homeostasis: Pancreatic Islets and Insulin Secretion
3.2K
The pancreatic islets comprising only 1%-2% of the volume are highly vascularized and innervated mini-organs. They contain five endocrine cell types, including β cells that secrete insulin, which is synthesized as a single polypeptide chain, preproinsulin, processed to proinsulin, and finally to insulin and C-peptide. This process is complex and regulated, involving the Golgi complex, the endoplasmic reticulum, and the secretory granules of the β cell.
Insulin and C-peptide are...
Insulin and C-peptide are...
3.2K
01:19Overview of Carbohydrate Metabolism
4.6K
Carbohydrate metabolism is a fundamental biochemical process that ensures a constant supply of energy to living cells. The most important carbohydrate is glucose, which can be broken down via glycolysis to enter into the Krebs cycle and eventually lead to the production of ATP through oxidative phosphorylation.
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
4.6K
01:17Hormones and Bone Tissue
4.3K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
4.3K
01:26Oral Hypoglycemic Agents: Biguanides and Glitazones
980
Biguanides, particularly metformin (Glucophage), are insulin sensitizers that enhance glucose uptake, thereby reducing insulin resistance. Unlike sulfonylureas, metformin doesn't prompt insulin secretion, which helps to curb hypoglycemia risk. Metformin is beneficial in treating conditions like polycystic ovary syndrome due to its insulin-resistance reduction capability. The drug's primary action involves curtailing hepatic gluconeogenesis, a significant contributor to high blood...
980