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Related Concept Videos

Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

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Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
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Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
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Diabetes: Symptoms, Diagnosis, and Complications01:15

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For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
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Diabetes: Management and Pharmacotherapy01:15

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The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
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Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
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Related Experiment Video

Updated: Apr 9, 2026

Behavioral Assessment of Visual Function via Optomotor Response and Cognitive Function via Y-Maze in Diabetic Rats
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The Diabetes Visual Function Supplement Study (DiVFuSS).

A Paul Chous1, Stuart P Richer2, Jeffry D Gerson3

  • 1Private Practice, Tacoma, Washington, USA.

The British Journal of Ophthalmology
|June 20, 2015
PubMed
Summary
This summary is machine-generated.

A novel supplement significantly improved visual function and reduced neuropathy in diabetes patients. This multi-component formula, containing xanthophyll pigments and antioxidants, showed benefits without impacting glycaemic control.

Keywords:
Clinical TrialColour visionField of visionMaculaRetina

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Area of Science:

  • Ophthalmology
  • Endocrinology
  • Nutritional Science

Background:

  • Diabetes mellitus impacts visual function even before retinopathy development.
  • Early visual function preservation may indicate intervention against diabetic retinopathy mechanisms.

Purpose of the Study:

  • To evaluate the efficacy of a novel multi-component supplement in improving visual function and other health markers in diabetic patients.
  • To assess the supplement's impact on visual acuity, neuropathy, and inflammatory markers.

Main Methods:

  • A 6-month randomized controlled trial involving type 1 and type 2 diabetes patients.
  • Participants received either a placebo or a multi-component supplement (xanthophylls, antioxidants, botanical extracts).
  • Visual function, neuropathy symptoms, and various biomarkers (lipids, hsCRP, HbA1c) were measured at baseline and 6 months.

Main Results:

  • The active supplement group showed significant improvements in all visual function measures compared to placebo.
  • Significant enhancements were observed in serum lipids, high-sensitivity C-reactive protein (hsCRP), and diabetic peripheral neuropathy.
  • No significant changes were noted in retinal thickness, HbA1c, total cholesterol, or TNF-α.

Conclusions:

  • The study demonstrates that the multi-component supplement leads to clinically meaningful improvements in visual function and peripheral neuropathy in diabetic patients.
  • The supplement positively impacts hsCRP levels without adversely affecting glycaemic control.
  • These findings suggest a potential therapeutic role for this supplement in managing diabetes-related complications.