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Draft Genome Sequence of the First Human Isolate of the Ruminant Pathogen Mycoplasma capricolum subsp. capricolum

Frederik Valeur Seersholm1, Anne Fischer, Martin Heller2

  • 1Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Copenhagen, Denmark frederikseersholm@gmail.com.

Genome Announcements
|June 20, 2015
PubMed

Insights

Mycoplasma capricolum subsp. capricolum, a pathogen in small ruminants, was recently found in a human septicemia case. This study presents the first draft genome sequence of this human isolate, aiding in understanding its human pathogenicity.

Area of Science:

  • Microbiology
  • Genomics
  • Infectious Diseases

Background:

  • Mycoplasma capricolum subsp. capricolum is a recognized pathogen in small ruminants.
  • A recent human septicemia case involved this Mycoplasma species, prompting investigation into its human pathogenicity.

Purpose of the Study:

  • To present the first draft genome sequence of a human isolate of Mycoplasma capricolum subsp. capricolum.
  • To provide genomic data that can help assess the potential pathogenicity of this bacterium in humans.

Main Methods:

  • Whole-genome sequencing of the human Mycoplasma capricolum subsp. capricolum isolate.
  • Bioinformatic analysis of the draft genome sequence.

Main Results:

  • The first draft genome sequence of a human-derived Mycoplasma capricolum subsp. capricolum isolate has been generated.
  • Genomic data is now available for further analysis regarding host adaptation and virulence in humans.

Conclusions:

  • The availability of this draft genome sequence is a crucial step in understanding the implications of Mycoplasma capricolum subsp. capricolum in human infections.
  • Further research utilizing this genomic data may elucidate the mechanisms behind potential human pathogenicity.

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