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Updated: Apr 9, 2026
07:43
Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
Published on: January 17, 2018
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Patient with inoperable pheochromocytoma.
D Brancíková1, Z Mechl1, Z Adam1
1Medical Faculty, Masaryk University, Brno, Czech Republic; ; Internal Hematological and Oncological Clinic, University Hospital Brno, Brno, Czech Republic;
Current Oncology (Toronto, Ont.)
|June 20, 2015
Summary
Malignant pheochromocytoma, a rare cancer, was treated effectively in a disseminated case using transarterial chemoembolization and systemic lanreotide and tegafur. This approach stabilized the disease and reduced catecholamine overproduction for an extended period.
Area of Science:
- Oncology
- Endocrinology
Background:
- Malignant pheochromocytoma is a rare tumor with low incidence.
- It can occur sporadically or be associated with multiple endocrine neoplasia.
Purpose of the Study:
- To present a case of sporadic malignant pheochromocytoma with widespread abdominal dissemination.
- To describe the treatment response and outcomes in this challenging clinical scenario.
Main Methods:
- The patient received local transarterial chemoembolization.
- Systemic treatment included lanreotide and later tegafur.
- Disease progression was monitored through imaging and catecholamine levels.
Main Results:
- Initial treatment with chemoembolization and lanreotide led to a significant decrease in catecholamine production for 20 months.
- Tegafur stabilized the disease for 50 months before discontinuation due to adverse effects.
- Maintenance therapy with lanreotide has shown no disease progression for 4 months.
Conclusions:
- Multidisciplinary management is crucial for malignant pheochromocytoma.
- A combination of locoregional and systemic therapies can achieve prolonged disease stabilization.
- Treatment strategies must be individualized based on disease extent and patient condition.
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