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Immunogenicity and Clinical Efficacy of Influenza Vaccination in Pregnancy

Alexander W Kay1, Catherine A Blish2

  • 1Blish Laboratory, Department of Pediatrics, Stanford University School of Medicine , Stanford, CA , USA.

Frontiers in Immunology
|June 20, 2015
PubMed

Pregnant women are at high risk from influenza due to disproportionate morbidity, mortality, and adverse pregnancy outcomes following infection. As such, they are classified as a high-priority group for vaccination. However, changes in the maternal immune system required to accommodate the allogeneic fetus may alter the immunogenicity of influenza vaccines. A large number of studies have evaluated the safety of the influenza vaccine. Here, we will review available studies on the immunogenicity and efficacy of the influenza vaccine during pregnancy, focusing on both humoral and cellular immunity.

Keywords:
antibodyimmunogenicityinactivated influenza vaccineinfluenzapregnancy

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