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Explicit Filtering Based Low-Dose Differential Phase Reconstruction Algorithm with the Grating Interferometry.

Xiaolei Jiang1, Li Zhang1, Ran Zhang1

  • 1Key Laboratory of Particle & Radiation Imaging (Tsinghua University), Ministry of Education, Beijing 100084, China ; Department of Engineering Physics, Tsinghua University, Beijing 100084, China.

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This study introduces a new low-dose differential phase reconstruction algorithm for X-ray grating interferometry. It enables artifact-free imaging from reduced scans, improving the study of weakly absorbing samples.

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Area of Science:

  • Medical Imaging
  • X-ray Physics
  • Computational Imaging

Background:

  • X-ray grating interferometry provides attenuation, differential phase contrast (DPC), and dark-field images from a single scan.
  • Differential phase contrast computed tomography (DPC-CT) reconstructs refractive indexes, offering complementary information to conventional attenuation imaging.
  • Existing DPC-CT methods often require extensive scanning and can be prone to artifacts.

Purpose of the Study:

  • To develop a novel, explicit filtering-based low-dose differential phase reconstruction algorithm for X-ray grating interferometry.
  • To enable artifact-free image reconstruction from reduced scanning protocols.
  • To improve the efficiency and reduce radiation dose in DPC-CT imaging.

Main Methods:

  • The proposed algorithm utilizes a differential algebraic reconstruction technique (DART).
  • It incorporates explicit filtering-based sparse regularization, differing from the commonly used total variation (TV) method.
  • Algorithm performance was validated through numerical simulations and experiments with biological samples.

Main Results:

  • The algorithm successfully reconstructs differential phase contrast images from reduced scanning data.
  • Artifacts commonly seen in low-dose or reduced-scan DPC-CT were significantly mitigated.
  • Both numerical and experimental results confirmed the algorithm's feasibility and effectiveness.

Conclusions:

  • The developed explicit filtering-based low-dose DPC reconstruction algorithm is effective for X-ray grating interferometry.
  • This method allows for high-quality phase imaging with reduced scanning time and radiation exposure.
  • The algorithm shows promise for advancing the application of DPC-CT in studying weakly absorbing samples.