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Updated: Apr 9, 2026

Author Spotlight: Exploring the Role of Ion Channels in Cancer: Characterization and Potential Treatment Approaches
Published on: June 16, 2023
Mitochondrial Ion Channels in Cancer Transformation
Stephen M Madamba1, Kevin N Damri2, Laurent M Dejean3
1Department of Natural Sciences, Baruch College, City University of New York , New York, NY , USA ; City University of New York Graduate Center , New York, NY , USA.
Abstract:
Cancer transformation involves reprograming of mitochondrial function to avert cell death mechanisms, monopolize energy metabolism, accelerate mitotic proliferation, and promote metastasis. Mitochondrial ion channels have emerged as promising therapeutic targets because of their connection to metabolic and apoptotic functions. This mini review discusses how mitochondrial channels may be associated with cancer transformation and expands on the possible involvement of mitochondrial protein import complexes in pathophysiological process.
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