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Updated: Apr 9, 2026

Direct Reprogramming of Mouse Fibroblasts into Melanocytes
Published on: August 27, 2021
Discoidin domain receptor-1 as a player in impairment of melanocytes adhesion process in vitiligo
Lamia H Elgarhy1, Amani Abdullatif, Rehab Abdelazim
1Department of Dermatology and Venereology, Tanta University, Tanta, Egypt - lamia_elgarhy@yahoo.com.
Background:
The aim of this paper was to study immunohistochemical expression of discoidin domain receptor 1 (DDR1) in lesional and non-lesional skin of vitiligo patients in comparison to controls, to explore its possible implication vitiligo pathogenesis.
Methods:
Twenty patients with non-segmental vitiligo (NSV) were subjected to punch biopsy from lesional and non-lesional vitiligo skin, in addition to punch biopsy from ten healthy subjects. All specimens were examined by H&E staining and by immunohistochemistry for DDR1 expression.
Results:
Significantly decreased expression of DDR1 in lesional vitiligo skin in comparison to non-lesional skin was observed. In addition, decreased lesional and non-lesional DDR1 expression in vitiligo skin in comparison to controls was found.
Conclusions:
Reduced DDR1 expression may be implicated in impaired melanocyte adhesion process involved in vitiligo pathogenesis.
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