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Antimicrobial Activity of Pomegranate and Green Tea Extract on Propionibacterium Acnes, Propionibacterium Granulosum,

Zhaoping Li, Paula H Summanen, Julia Downes

    Journal of Drugs in Dermatology : JDD
    |June 20, 2015
    PubMed

    Insights

    Pomegranate extract (POMx) and green tea extract (GT) show potent antibacterial activity against acne-causing bacteria. These natural compounds may offer a safer alternative to current acne treatments.

    Area of Science:

    • Dermatology
    • Microbiology
    • Natural Products Chemistry

    Background:

    • Acne vulgaris is a common skin condition often exacerbated by bacterial infections.
    • Propionibacterium acnes, Propionibacterium granulosum, Staphylococcus aureus, and Staphylococcus epidermidis are key bacteria implicated in acne pathogenesis.
    • Current acne treatments can have side effects, driving the search for natural alternatives.

    Purpose of the Study:

    • To evaluate the in vitro antibacterial activity of pomegranate extract (POMx), pomegranate juice (POM juice), and green tea extract (GT) against acne-associated bacteria.
    • To determine the minimum inhibitory concentrations (MICs) of these natural extracts.
    • To assess the potential of POMx and GT as preventative or therapeutic agents for acne.

    Main Methods:

    • Minimum inhibitory concentrations (MICs) were determined using the Clinical and Laboratory Standards Institute-approved agar dilution technique.
    • Bacterial strains included Propionibacterium acnes, Propionibacterium granulosum, Staphylococcus aureus, and Staphylococcus epidermidis.
    • Phytochemical analysis involved Folin-Ciocalteu for total phenolics and HPLC for polyphenol composition.

    Main Results:

    • Green tea extract (GT) demonstrated potent activity, with MICs ≤400 μg/ml for 98% of strains.
    • Pomegranate extract (POMx) showed significant efficacy against Propionibacterium acnes (64% at 50 μg/ml) and Staphylococcus epidermidis (at 25 μg/ml).
    • Both POMx and GT exhibited inhibitory activity against all tested Propionibacterium granulosum and Staphylococcus aureus strains at concentrations ≤400 μg/ml.

    Conclusions:

    • Pomegranate extract and green tea extract possess significant in vitro antibacterial properties against common acne-related bacteria.
    • These natural extracts demonstrate potential as effective and possibly safer alternatives for acne management.
    • Further research into POMx and GT could lead to novel preventative or therapeutic strategies for acne vulgaris.

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