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Updated: Apr 9, 2026

Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning

Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning

Published on: April 16, 2018

Hydrogel Nanofilaments via Core-Shell Electrospinning.

Paweł Nakielski¹, Sylwia Pawłowska¹, Filippo Pierini¹

¹Department of Mechanics and Physics of Fluids, Institute of Fundamental Technological Research, Polish Academy of Sciences, Warsaw, Poland.

|June 20, 2015

Summary

Researchers developed flexible hydrogel nanofilaments using core-shell electrospinning. These nanostructures exhibit DNA-like elasticity and dynamics, suitable for drug delivery and microfluidics.

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Microfluidic Fabrication of Polymeric and Biohybrid Fibers with Predesigned Size and Shape

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Related Experiment Videos

Last Updated: Apr 9, 2026

Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning

Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning

Published on: April 16, 2018

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Microfluidic Fabrication of Polymeric and Biohybrid Fibers with Predesigned Size and Shape

Microfluidic Fabrication of Polymeric and Biohybrid Fibers with Predesigned Size and Shape

Published on: January 8, 2014

Area of Science:

Biomaterials Science
Nanotechnology
Polymer Chemistry

Background:

Biomedical applications demand nanostructures with tunable mechanical properties and controlled dimensions.
Existing hydrogels often lack the required flexibility and deformability for advanced applications.

Purpose of the Study:

To present a novel technique for fabricating highly deformable hydrogel nanofilaments.
To create nanostructures with elasticity and deformability comparable to DNA chains.
To enable applications in drug delivery and microfluidics.

Main Methods:

Utilized core-shell electrospinning technique.
Incorporated core solution polymerization post-electrospinning.
Characterized nanofilaments using atomic force microscopy (AFM) nanoindentation tests.

Main Results:

Successfully produced highly deformable hydrogel nanofilaments.
Demonstrated Brownian motion and bending dynamics of the nanofilaments.
Evaluated and compared mechanical properties via AFM nanoindentation.

Conclusions:

The developed method yields flexible hydrogel nanofilaments with DNA-like properties.
These nanofilaments are promising for drug delivery and microfluidic applications.
The technique offers control over nanostructure properties for biomedical engineering.