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Assessment of Human Natural Killer Cell Events Driven by FcγRIIIa Engagement in the Presence of Therapeutic Antibodies
Published on: May 22, 2020
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Fcγ-receptor tag team boosts anti-tumor immunity
Frederick Arce Vargas1, Sergio A Quezada1
1Cancer Immunology Unit, UCL Cancer Institute, University College London, 72 Huntley Street, London, WC1E 6DD, UK.
Trends in Immunology
|June 21, 2015
Abstract:
Anti-tumor monoclonal antibodies eliminate tumor cells through different mechanisms including antibody-mediated cell cytotoxicity and generation of long-term anti-tumor T cell responses. In a recent publication, DiLillo and Ravetch demonstrate how this vaccinal effect is mediated by engagement of Fcγ receptors expressed on antigen-presenting cells.

