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Parma consensus statement on metabolic disruptors.

Jerrold J Heindel1, Frederick S Vom Saal2, Bruce Blumberg3

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Environmental chemicals, termed metabolic disruptors, are linked to obesity and metabolic disorders. Experts reviewed data to identify knowledge gaps and propose a broader definition to advance research on these widespread health concerns.

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Area of Science:

  • Environmental Health
  • Endocrinology
  • Toxicology

Background:

  • Growing concern exists regarding environmental chemicals influencing metabolic disorders.
  • Obesity and metabolic syndrome are complex diseases with potential environmental contributors.

Purpose of the Study:

  • To review current scientific findings on environmental metabolic disruptors and their link to obesity.
  • To identify reliable conclusions from animal and human studies.
  • To define knowledge gaps and propose future research directions.

Main Methods:

  • A workshop convened multidisciplinary experts in Parma, Italy (May 16-18, 2014).
  • Review of recent animal model and epidemiological studies.
  • Consensus-building on existing data and uncertainties.

Main Results:

  • Environmental chemicals, termed metabolic disruptors, show potential links to obesity and metabolic syndrome.
  • Certain conclusions can be drawn from current animal and human data.
  • Critical knowledge gaps and areas of uncertainty were identified.

Conclusions:

  • The definition of obesogens should be broadened to "metabolic disruptors."
  • Metabolic disruptors encompass chemicals affecting susceptibility to obesity, diabetes, and metabolic syndrome.
  • Further research is needed to understand the role of environmental chemical exposures in metabolic disease epidemics.