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Modulation of T cell response by Phellinus linteus.

Chun-Jung Lin1, Hsiu-Man Lien2, Hwai-Jeng Lin3

  • 1Graduate Institute of Clinical Medical Science, China Medical University, 91 Hsuehshih Road, Taichung 40402, Taiwan; Department of Urology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA.

Journal of Bioscience and Bioengineering
|June 21, 2015
PubMed
Summary

Phellinus linteus fermented broths, rich in polysaccharides, effectively regulate T cell activation. These mushroom extracts show promise for developing new immunomodulatory therapeutics by balancing Th1/Th2 immune responses.

Keywords:
Cell cycleCytokinePhellinus linteusPolysaccharideTh1/Th2 balance

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Area of Science:

  • Mycology
  • Immunology
  • Pharmacology

Background:

  • Phellinus linteus mushrooms possess known anti-inflammatory and immunomodulatory properties.
  • Polysaccharides are key bioactive compounds in medicinal mushrooms.
  • Understanding the specific immunoregulatory effects of P. linteus constituents is crucial for therapeutic development.

Purpose of the Study:

  • To analyze polysaccharides in P. linteus fermented broths.
  • To evaluate the immunoregulatory effects of these broths on T cells.
  • To identify effective P. linteus components for therapeutic applications.

Main Methods:

  • Preparation of four P. linteus fermented broths (PL1-4) and dialyzate medium (MD).
  • Analysis of polysaccharide content in each sample.
  • Assessment of biological activity on T cell activation, including interleukin-2 (IL-2) production and cell cycle progression.
  • Measurement of interferon-gamma (IFN-γ) and interleukin-4 (IL-4) ratios.

Main Results:

  • P. linteus broths (PL3 and MD) dose-responsively inhibited IL-2 production and cell cycle progression in T cells, inducing S phase arrest.
  • PL3 broth, high in polysaccharides, significantly reduced the IFN-γ to IL-4 ratio.
  • These findings indicate an additive effect on Th1/Th2 balance regulation.

Conclusions:

  • Phellinus linteus fermented broths, particularly polysaccharide-rich fractions, modulate T cell responses.
  • These broths demonstrate potential for developing novel immunomodulatory therapeutics.
  • Further research into P. linteus constituents could lead to treatments for immune-related disorders.