[Gaucher's disease and pregnancy]

Area of Science:

• Hepatology
• Hematology
• Genetics

Background:

• Gaucher's disease is a rare genetic disorder.
• Chronic Gaucher's disease often presents with subtle, long-undiagnosed symptoms.

Observation:

• A female patient with undiagnosed chronic Gaucher's disease experienced disease progression during pregnancy.
• Pregnancy exacerbated liver cellular failure and hemorrhagic complications.

Findings:

• Splenectomy led to stable remission of Gaucher's disease.
• Following splenectomy, the patient achieved a normal pregnancy and delivery.

Implications:

• This case highlights the impact of pregnancy on Gaucher's disease progression.
• Splenectomy can be an effective treatment for managing severe Gaucher's disease, enabling successful pregnancy outcomes.