Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Factors influencing heart rate variability in nurses following night shifts: a prospective observational clinical study.

BMC nursing·2025

Same author

The impact of working night shifts on cardiac autonomic nervous regulation during the six-minute walk test in nurses.

BMC nursing·2024

Same author

Association between the stress-hyperglycemia ratio and all-cause mortality in community-dwelling populations: An analysis of the National Health and Nutrition Examination Survey (NHANES) 1999-2014.

Journal of diabetes·2024

Same author

The ECG abnormalities in persons with chronic disorders of consciousness.

Medical & biological engineering & computing·2024

Same author

Long-pulsed ultrasound-mediated microbubble thrombolysis in a rat model of microvascular obstruction.

Open medicine (Warsaw, Poland)·2024

Same author

Campylobacter fetus-induced primary psoas abscess in patient with gouty arthritis: A case report and literature review.

Medicine·2023

Search research articles

Related Experiment Video

Updated: Apr 9, 2026

Methods for Acute and Subacute Murine Hindlimb Ischemia

Methods for Acute and Subacute Murine Hindlimb Ischemia

Published on: June 21, 2016

Drag-reducing polymers increase exercise tolerance in an ischemic hind-limb rat model.

Quan Zhang¹, Yuanyan Deng², Wenjing Zhang²

¹Department of Cardiology, Affiliated Hospital of Weifang Medical University, Weifang, Shandong, China.

|June 21, 2015

Summary

Drag-reducing polymers enhanced exercise endurance in rats with hind-limb ischemia. These polymers improved exercise time and reduced muscle lactic acid, indicating an anti-fatigue effect.

Keywords:

Drag-reducing polymer acute limb ischemia exhaustive exercise polyethylene oxide

More Related Videos

A Modified Surgical Model of Hind Limb Ischemia in ApoE-/- Mice using a Miniature Incision

A Modified Surgical Model of Hind Limb Ischemia in ApoE-/- Mice using a Miniature Incision

Published on: May 13, 2021

Preclinical Model of Hind Limb Ischemia in Diabetic Rabbits

Preclinical Model of Hind Limb Ischemia in Diabetic Rabbits

Published on: June 2, 2019

Related Experiment Videos

Last Updated: Apr 9, 2026

Methods for Acute and Subacute Murine Hindlimb Ischemia

Methods for Acute and Subacute Murine Hindlimb Ischemia

Published on: June 21, 2016

A Modified Surgical Model of Hind Limb Ischemia in ApoE-/- Mice using a Miniature Incision

A Modified Surgical Model of Hind Limb Ischemia in ApoE-/- Mice using a Miniature Incision

Published on: May 13, 2021

Preclinical Model of Hind Limb Ischemia in Diabetic Rabbits

Preclinical Model of Hind Limb Ischemia in Diabetic Rabbits

Published on: June 2, 2019

Area of Science:

Biomedical Engineering
Physiology
Pharmacology

Background:

Drag-reducing polymers are blood-soluble macromolecules known to improve microcirculation.
Hind-limb ischemia models are used to study conditions affecting limb blood flow and exercise capacity.

Purpose of the Study:

To investigate the efficacy of drag-reducing polymers in improving exercise tolerance.
To assess the anti-fatigue effects of drag-reducing polymers in a rat model of hind-limb ischemia.

Main Methods:

Bilateral femoral artery ligation was performed on Wistar rats to induce hind-limb ischemia.
Rats received either polyethylene oxide (drag-reducing polymer) or saline intravenously during exhaustive exercise.
Exercise duration, muscle and serum lactic acid, nitric oxide, creatine kinase, and lactate dehydrogenase levels were measured.

Main Results:

Polyethylene oxide treatment significantly increased exhaustive exercise time compared to saline controls.
Rats treated with polyethylene oxide showed lower lactic acid levels in gastrocnemius muscle.
Nitric oxide levels were elevated in the polyethylene oxide group, suggesting improved vascular function.

Conclusions:

Drag-reducing polymers demonstrate a significant positive impact on exercise endurance.
These polymers exhibit anti-fatigue properties, potentially by improving microcirculation and metabolic profiles.
The findings suggest therapeutic potential for drag-reducing polymers in conditions characterized by impaired exercise capacity.