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[Is the Sodium Thiosulfate Therapy useful for vascular calcification in dialysis Pts?]

Giulia Ghiandai, Chiara Ralli, Patrizio Imperiali

    Giornale Italiano Di Nefrologia : Organo Ufficiale Della Societa Italiana Di Nefrologia
    |June 21, 2015
    PubMed

    Insights

    Sodium thiosulfate (STS) may help reduce vascular calcifications in hemodialysis patients. This study found STS improved leg pain and fatigue, though calcification markers showed only modest changes.

    Area of Science:

    • Nephrology
    • Cardiovascular Medicine
    • Pharmacology

    Background:

    • Vascular calcifications are a significant risk factor for cardiovascular morbidity and mortality in uremic patients.
    • Sodium thiosulfate (STS) has demonstrated potential in mitigating uremic calcification progression in hemodialysis patients.

    Purpose of the Study:

    • To evaluate the effects of intravenously administered Sodium thiosulfate (STS) on aortic calcification progression and associated symptoms in hemodialysis patients.
    • To assess changes in calcification index, mineral metabolism, parathyroid hormone (PTH), and oral chelation therapy during STS treatment.

    Main Methods:

    • 18 hemodialysis patients received 10 grams of STS infused during the final 2 hours of dialysis sessions for 6 months.
    • Evaluated Kauppila's calcification index, calcium-phosphorus metabolism, PTH levels, and oral chelation therapy.
    • Assessed STS side effects and patient-reported symptomatic improvements via questionnaire.

    Main Results:

    • A modest reduction in Kauppila's calcification index was observed (16.4 ± 5.5 to 15.1 ± 4.6).
    • No significant changes in calcium-phosphorus metabolism or PTH levels were detected.
    • Statistically significant improvements in leg pain, power reserve, and reduced muscle fatigue were reported.

    Conclusions:

    • Preliminary findings suggest Sodium thiosulfate (STS) may positively impact vasculopathic symptoms in hemodialysis patients.
    • STS shows potential in slowing the progression of vascular calcifications, warranting further investigation in larger cohorts.

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