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Increased Prevalence of Coronary Artery Disease in Severe Psoriasis and Severe Atopic Dermatitis

Kasper Fjellhaugen Hjuler1, Morten Böttcher2, Christian Vestergaard1

  • 1Department of Dermatology, Aarhus University Hospital, Aarhus, Denmark.

The American Journal of Medicine
|June 21, 2015
PubMed

Insights

Psoriasis and atopic dermatitis (AD) patients show higher rates of coronary artery disease (CAD). Psoriasis is linked to more severe CAD, indicating a need for cardiovascular monitoring in these inflammatory skin conditions.

Area of Science:

  • Dermatology
  • Cardiology
  • Immunology

Background:

  • Psoriasis and atopic dermatitis (AD) are chronic inflammatory diseases.
  • While AD is linked to systemic inflammation, psoriasis is also associated with cardiovascular disease.
  • The study investigates coronary artery disease (CAD) in patients with psoriasis and AD.

Purpose of the Study:

  • To determine the prevalence, severity, and subtype of CAD in patients with psoriasis and AD.
  • To compare CAD findings in these patient groups against a control group.
  • To assess cardiovascular risk in individuals with these immuno-inflammatory skin conditions.

Main Methods:

  • Cardiac computed tomography angiography (CCTA) was used to examine patients.
  • An 18-segment model of the coronary tree was employed for assessment.
  • Study included patients with psoriasis (n=58), AD (n=31), and matched controls (n=33).

Main Results:

  • Psoriasis patients had a higher prevalence of coronary artery calcium scores ≥100 (19.3% vs 2.9% in controls).
  • Psoriasis was associated with increased significant coronary stenosis (>70%) and multi-vessel disease.
  • AD patients showed a higher prevalence of mild, single-vessel disease compared to controls.

Conclusions:

  • Psoriasis and AD are associated with a higher prevalence of coronary artery disease.
  • Psoriasis patients exhibit an increased prevalence of severe coronary artery disease.
  • These findings highlight the importance of cardiovascular assessment in patients with psoriasis and AD.
Abstract

Keywords:
AtherosclerosisAtopic dermatitisCardiac computed tomography angiographyCardiovascular diseasePsoriasis

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