Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

4.0K
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
4.0K
Overview of the Vascular System01:20

Overview of the Vascular System

3.8K
The vascular system comprises an extensive network of arteries, capillaries, and veins. The vascular system can be broadly divided into the blood and lymphatic systems. Typically, blood vessels can be categorized into three histological regions: tunica intima, tunica media, and tunica adventitia. The tunica intima consists of a single layer of endothelial cells attached to the basal lamina. Underlying the basal lamina is a connective tissue layer and an elastic lamina that gives stability and...
3.8K
Inflammatory Response I: Vascular and Cellular01:30

Inflammatory Response I: Vascular and Cellular

18.9K
The inflammatory response is the body's defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps locate and destroy pathogens and remove damaged tissue elements to heal the body. During this initial phase, fluid, blood products, and nutrients migrate to the injured area, resulting in redness, heat, swelling, ache, and loss of function. Moreover, signs of systemic inflammation include fever, increased WBC count, malaise, anorexia, nausea,...
18.9K
Mechanism of Angiogenesis01:10

Mechanism of Angiogenesis

7.7K
Blood vessel formation starts early during embryonic development, around day 7. In the extraembryonic yolk sac, mesodermal precursor cells called hemangioblast proliferate and differentiate into angioblast. Angioblasts express vascular endothelial growth factor receptor 2 or VEGFR2, which binds VEGF-A, a proangiogenic factor, guiding blood vessel formation. VEGF signaling promotes angioblasts to form a blood island in the developing embryo. Angioblasts further differentiate, giving rise to...
7.7K
Psychoneuroimmunology: Cardiovascular Disease01:27

Psychoneuroimmunology: Cardiovascular Disease

700
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
700
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

16.8K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
16.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Rheumatoid factor production is genetically and molecularly distinct from rheumatoid arthritis.

The Journal of clinical investigation·2026
Same author

Large-scale, spatially resolved panoramic CRISPR screening in native tissue environments using Perturb-DBiT.

Nature biotechnology·2026
Same author

Limitations of ultrasonography in the assessment of aortic involvement in giant cell arteritis: comment on the article by Bull Haaversen et al.

Arthritis care & research·2026
Same author

Rare Gain-of-Function Variants in IDH1 and IDH2 Confer Increased Risk of Immune-Mediated Rheumatic Diseases.

ACR open rheumatology·2026
Same author

Identifying Systemic Lupus Erythematosus From Serum Proteomic Profiles Using Machine Learning and Genetic Risk Stratification.

Arthritis & rheumatology (Hoboken, N.J.)·2026
Same author

Type I interferon drives dysfunction of a distinct CD8+ HLA-DRB1+ T cell subset in systemic lupus erythematosus.

medRxiv : the preprint server for health sciences·2026

Related Experiment Video

Updated: Apr 9, 2026

Supervised Machine Learning for Semi-Quantification of Extracellular DNA in Glomerulonephritis
09:16

Supervised Machine Learning for Semi-Quantification of Extracellular DNA in Glomerulonephritis

Published on: June 18, 2020

7.4K

Epigenetics and Vasculitis: a Comprehensive Review.

Paul Renauer1, Patrick Coit1, Amr H Sawalha2,3,4

  • 1Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.

Clinical Reviews in Allergy & Immunology
|June 22, 2015
PubMed
Summary

Epigenetic changes are increasingly recognized in vasculitis, a group of rare inflammatory blood vessel diseases. Understanding these epigenetic mechanisms offers new therapeutic targets and biomarkers for vasculitis.

Keywords:
DNA methylationEpigeneticsHistone modificationVasculitismiRNA

More Related Videos

Author Spotlight: Investigating Angiogenesis and Vessel Permeability Through a Modified Matrix Gel Plug Assay
09:03

Author Spotlight: Investigating Angiogenesis and Vessel Permeability Through a Modified Matrix Gel Plug Assay

Published on: June 30, 2023

1.9K
In Vivo Vascular Permeability Detection in Mouse Submandibular Gland
07:10

In Vivo Vascular Permeability Detection in Mouse Submandibular Gland

Published on: August 4, 2022

2.7K

Related Experiment Videos

Last Updated: Apr 9, 2026

Supervised Machine Learning for Semi-Quantification of Extracellular DNA in Glomerulonephritis
09:16

Supervised Machine Learning for Semi-Quantification of Extracellular DNA in Glomerulonephritis

Published on: June 18, 2020

7.4K
Author Spotlight: Investigating Angiogenesis and Vessel Permeability Through a Modified Matrix Gel Plug Assay
09:03

Author Spotlight: Investigating Angiogenesis and Vessel Permeability Through a Modified Matrix Gel Plug Assay

Published on: June 30, 2023

1.9K
In Vivo Vascular Permeability Detection in Mouse Submandibular Gland
07:10

In Vivo Vascular Permeability Detection in Mouse Submandibular Gland

Published on: August 4, 2022

2.7K

Area of Science:

  • Immunology
  • Genetics
  • Rheumatology

Background:

  • Vasculitides are rare systemic inflammatory diseases of blood vessels with incompletely understood etiology.
  • Epigenetic dysregulation is implicated in immune-mediated diseases, with growing evidence in vasculitis.
  • Specific epigenetic modifications are linked to anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis, Kawasaki disease, and IgA vasculitis.

Purpose of the Study:

  • To review the current understanding of epigenetic contributions to the pathogenesis of various vasculitides.
  • To highlight recent genome-wide epigenomic studies in vasculitis.
  • To explore the potential of epigenetic insights for novel therapeutic strategies and biomarkers.

Main Methods:

  • Review of existing literature on epigenetic mechanisms in vasculitis.
  • Analysis of genome-wide DNA methylation studies in Behçet's disease and giant cell arteritis.
  • Examination of histone modifications in PR3 and MPO gene loci in ANCA-associated vasculitis.

Main Results:

  • Epigenetic remodeling of cytoskeleton-related genes is implicated in Behçet's disease pathogenesis, with potential reversal upon remission.
  • Genome-wide DNA methylation profiling in giant cell arteritis revealed activated calcineurin/NFAT signaling.
  • Histone modifications at PR3 and MPO loci may play a role in ANCA-associated vasculitis.

Conclusions:

  • Epigenetic dysregulation is a significant factor in the pathogenesis of systemic vasculitis.
  • Investigating epigenetic mechanisms provides insights into disease development and identifies potential therapeutic targets.
  • Further research into epigenetics holds promise for developing novel biomarkers and treatments for vasculitis.