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Hepatitis

Hepatitis

Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver.

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Related Experiment Video

Updated: Apr 9, 2026

A Competent Hepatocyte Model Examining Hepatitis B Virus Entry through Sodium Taurocholate Cotransporting Polypeptide as a Therapeutic Target

A Competent Hepatocyte Model Examining Hepatitis B Virus Entry through Sodium Taurocholate Cotransporting Polypeptide as a Therapeutic Target

Published on: May 10, 2022

Donors With Hepatitis B Surface Antigen Positivity.

H Asuman Yavuz¹, S Tekin², Y Yuksel³

¹Department of Nephrology and Renal Transplantation, Atakent Education and Research Hospital, Acıbadem University, İstanbul, Turkey.

Transplantation Proceedings

|June 22, 2015

Summary

Hepatitis B surface antigen-positive donors can safely provide kidneys for transplantation. This study found no significant differences in patient or graft outcomes compared to HBsAg-negative donors, supporting their use in living kidney donation.

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Last Updated: Apr 9, 2026

A Competent Hepatocyte Model Examining Hepatitis B Virus Entry through Sodium Taurocholate Cotransporting Polypeptide as a Therapeutic Target

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Modeling Hepatitis B Virus Infection in Non-Hepatic 293T-NE-3NRs Cells

Modeling Hepatitis B Virus Infection in Non-Hepatic 293T-NE-3NRs Cells

Published on: June 5, 2020

Area of Science:

Nephrology
Hepatology
Transplantation Immunology

Background:

Controversy exists regarding the use of hepatitis B surface antigen (HBsAg)-positive donors for renal transplantation.
Previous reports suggest feasibility under specific protocols.

Purpose of the Study:

To compare clinical and biochemical parameters of kidney recipients from HBsAg-positive donors versus HBsAg-negative donors.
To evaluate the safety and efficacy of using HBsAg-positive donors in living-related renal transplantation.

Main Methods:

Retrospective analysis of 2168 living-related renal transplantations.
Comparison between 111 HBsAg-positive donors (group 1) and 2057 HBsAg-negative donors (group 2).
Strict protocol for group 1: recipient hepatitis B antibody titer >10 mIU/mL and donor hepatitis B virus DNA negative.

Main Results:

Similar 1-, 2-, and 4-year serum creatinine, glomerular filtration rates, and liver function tests between groups.
No new hepatitis B virus infections observed during the study.
Comparable rates of acute rejection, graft loss, and patient loss between group 1 and group 2.

Conclusions:

Hepatitis B surface antigen positivity is not an absolute contraindication for living kidney donation.
Living-related renal transplantation from HBsAg-positive donors can achieve outcomes similar to HBsAg-negative donors when specific protocols are followed.