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Related Concept Videos

Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
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Stem Cell Culture01:17

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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
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The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
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Mesenchymal Stem Cells01:19

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Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
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Targeted and Selective Treatment of Pluripotent Stem Cell-derived Teratomas Using External Beam Radiation in a Small-animal Model
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Stem Cell-Based Therapies for Cancer.

Deepak Bhere1, Khalid Shah1

  • 1Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Advances in Cancer Research
|June 22, 2015
PubMed
Summary

Stem cells are promising for cancer therapy, acting as delivery systems for targeted treatments. Research highlights their potential in delivering proteins and viruses to combat various cancer types effectively.

Keywords:
Cancer therapyDelivery vehiclesInduced pluripotent stem cellsMesenchymal stem cellsMigrationMolecular imagingNeural stem cellsTargeted therapy

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Area of Science:

  • * Regenerative Medicine
  • * Oncology
  • * Cell Biology

Background:

  • * Stem cell therapies are increasingly recognized for their therapeutic potential.
  • * Stem cells are being explored as advanced delivery systems in cancer treatment.
  • * These cells can transport therapeutic agents like proteins and viruses directly to tumors.

Purpose of the Study:

  • * To review studies utilizing stem cells for cancer therapy.
  • * To emphasize the role of stem cells as targeted delivery vehicles.
  • * To identify critical factors for successful future stem cell-based cancer treatments.

Main Methods:

  • * Comprehensive literature review of stem cell applications in oncology.
  • * Analysis of studies employing stem cells to deliver therapeutic proteins.
  • * Examination of research on stem cells delivering oncolytic viruses.
  • * Focus on strategies targeting diverse cancer types.

Main Results:

  • * Numerous studies demonstrate successful application of stem cell-based strategies.
  • * Stem cells effectively deliver targeted proteins and viruses in various cancer models.
  • * Evidence supports the potential of stem cells in diverse oncological interventions.

Conclusions:

  • * Stem cell-based delivery systems show significant promise in cancer therapy.
  • * Successful implementation requires careful consideration of critical success factors.
  • * Future research should focus on optimizing these strategies for clinical translation.