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Cerebrospinal fluid eosinophilia in a child with neuroborreliosis

Piotr Buda, Konrad Zawadka, Weronika Wadowska-Kłopotek

    Wiadomosci Lekarskie (Warsaw, Poland : 1960)
    |June 23, 2015
    PubMed

    Insights

    Cerebrospinal fluid eosinophilia, a rare finding, was observed in an 8-year-old boy. This case report details the first documented instance of borreliosis presenting with cerebrospinal fluid eosinophilia.

    Area of Science:

    • Neurology
    • Infectious Diseases
    • Immunology

    Background:

    • Cerebrospinal fluid (CSF) eosinophilia is uncommon, typically linked to helminthic infections causing eosinophilic meningitis.
    • It can also indicate other conditions like bacterial/fungal meningitis, malignancies, shunts, hypereosinophilic syndrome, or drug allergies.

    Observation:

    • An 8-year-old boy presented with fever and meningitis symptoms.
    • Analysis of his cerebrospinal fluid revealed significant eosinophilia.

    Findings:

    • Further serological testing confirmed a diagnosis of borreliosis.
    • This marks the first reported case of Borrelia burgdorferi infection associated with CSF eosinophilia.

    Implications:

    • This finding expands the differential diagnosis for cerebrospinal fluid eosinophilia.
    • It suggests that borreliosis should be considered in cases of unexplained CSF eosinophilia, even without typical Lyme disease symptoms.

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