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Related Concept Videos

Heart Failure Drugs: Inotropic Agents01:26

Heart Failure Drugs: Inotropic Agents

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Positive inotropic agents are commonly used as the first line of treatment for heart failure. One such agent is digoxin, derived from the genus Digitalis, which has been known for centuries but effectively utilized since 1785. However, these cardiac glycosides can have potentially toxic effects due to their mechanism of action, which involves inhibiting Na+/K+-ATPase and increasing contractility. Digoxin is absorbed orally and distributed in various tissues, including the CNS. It has a long...
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Drug toxicity: Drug–Drug Interaction01:30

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Drug–drug interactions can precipitate toxicity through multiple mechanisms. Absorption interactions alter how drugs enter the body, exemplified when ranitidine increases the absorption of basic drugs, while cholestyramine decreases the levels of propranolol. Protein binding interactions occur when drugs share the same binding sites on plasma proteins. Drugs like aspirin and warfarin, when bound in excess, can lead to increased free drug concentrations, enhancing the potential for...
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Parkinson's Disease: Treatment01:24

Parkinson's Disease: Treatment

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Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
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Drug Accumulation During Multiple Dosing: Intermittent IV Infusions01:24

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Intermittent intravenous (IV) infusion is a method of drug administration where medications are delivered over short infusion periods followed by intervals of no drug delivery. This approach helps to prevent sustained high drug concentrations in the bloodstream, reducing the risk of adverse effects associated with prolonged exposure. Unlike continuous infusion, steady-state concentrations may not be achieved during a single dosing cycle but can be reached through repeated...
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Therapeutic Drug Monitoring: Drug Analysis Methods01:26

Therapeutic Drug Monitoring: Drug Analysis Methods

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Therapeutic Drug Monitoring (TDM) is a clinical practice that measures specific drug levels in a patient's blood or body tissues to tailor drug therapy effectively. This monitoring is critical for managing drugs with narrow therapeutic indices like digoxin and phenytoin, ensuring they are both safe and effective. For instance, monitoring theophylline levels in asthma patients involves precision and sensitivity to adjust doses according to individual responses to therapy, ensuring efficacy and...
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Therapeutic Drug Monitoring: Overview and Classification01:16

Therapeutic Drug Monitoring: Overview and Classification

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Therapeutic Drug Monitoring (TDM) is a clinical practice that measures specific drug levels in a patient's blood at designated intervals to ensure the drug concentration stays within a therapeutic range. This monitoring is crucial for optimizing individual dosage regimens, enhancing therapeutic efficacy, and minimizing drug-related toxicity. TDM is vital for drugs with narrow therapeutic windows, significant variability in pharmacokinetics, and a clear correlation between plasma levels and...
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Related Experiment Video

Updated: Apr 9, 2026

Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro
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Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro

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Polydatin: a new therapeutic agent against multiorgan dysfunction.

Zhenhua Zeng1, Zhongqing Chen1, Tao Li2

  • 1Guangdong Key Laboratory of Shock and Microcirculation Research, Department of Pathophysiology, Southern Medical University, Guangzhou, P.R. China; Department of Critical Care Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, P.R. China.

The Journal of Surgical Research
|June 23, 2015
PubMed
Summary

Polydatin (PD) shows therapeutic potential for multiple-organ dysfunction syndrome (MODS) by improving organ function and survival. This natural compound effectively reduces oxidative stress, inflammation, and apoptosis in MODS.

Keywords:
ApoptosisInflammationMultiorgan dysfunction syndromeOxidative stressPolydatin

Related Experiment Videos

Last Updated: Apr 9, 2026

Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro
11:06

Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro

Published on: January 31, 2022

5.6K

Area of Science:

  • Biomedical Science
  • Pharmacology
  • Toxicology

Background:

  • Polydatin (PD), a natural polyphenolic compound, is known for its protective effects against mitochondrial dysfunction.
  • While PD is approved for shock treatment, its efficacy in multiple-organ dysfunction syndrome (MODS) remains under investigation.

Purpose of the Study:

  • To investigate the therapeutic potential of Polydatin (PD) in a rat model of multiple-organ dysfunction syndrome (MODS).
  • To evaluate the effects of PD on organ function, survival, oxidative stress, inflammation, and apoptosis in MODS.

Main Methods:

  • MODS was induced in Sprague-Dawley rats using hemorrhage and cecal ligation/puncture.
  • Rats were treated with PD, normal saline, or no treatment.
  • Evaluated survival, biochemical markers, histopathology, oxidative stress (AOPPs), inflammatory cytokines, and apoptosis-related proteins (Bcl-2, Bax, caspase-3).

Main Results:

  • PD administration significantly improved organ function and prolonged survival time in MODS rats.
  • PD reduced the incidence of MODS and decreased serum levels of advanced oxidative protein products (AOPPs) and proinflammatory cytokines.
  • PD suppressed apoptosis by decreasing Bax and increasing Bcl-2 levels and reducing caspase-3 activity in the kidney and liver.

Conclusions:

  • Polydatin (PD) demonstrates significant therapeutic potential for MODS.
  • PD exerts its protective effects by suppressing oxidative stress, inhibiting inflammation, and attenuating apoptosis.
  • PD may serve as a promising therapeutic agent for MODS, protecting against mitochondrial dysfunction.