Two new sesquiterpenoids from cultures of the basidiomycete Tremella foliacea
Related Experiment Video
Updated: Apr 9, 2026

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Jian-Hai Ding1,2,3, Zheng-Hui Li1, Kun Wei3
1a School of Pharmaceutical Sciences, South-Central University for Nationalities , Wuhan 430074 , China.
Abstract:
Two new sesquiterpenoids, trefoliol B (1) and trefoliol C (2), together with known echinocidin A (3), were isolated from cultures of the basidiomycetes Tremella foliacea. The new structures were elucidated on the basis of extensive spectroscopic methods. At the same time, trefoliol B (1) and echinocidin A (3) were tested for their cytotoxicities against five human cancer cell lines and for their inhibitory activities against isozymes of 11β-hydroxysteroid dehydrogenases (11β-HSD). No compound showed significant activity (IC50 > 40 μM). Compound 1 showed moderate inhibitory activities against 11β-HSD1 (human IC50 = 13.1 μM; mouse IC50 = 91.8 μM).
Related Concept Videos
Antifungal Agents
Fungal Phylum Basidiomycota
Anthelminthic Agents

