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Related Concept Videos

Factors Affecting the Risk of Infection01:26

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The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
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Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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Related Experiment Video

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Knee Arthrocentesis in Adults
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Infections and arthritis.

Ashish Jacob Mathew1, Vinod Ravindran2

  • 1Department of Clinical Immunology and Rheumatology, Christian Medical College, Vellore, India.

Best Practice & Research. Clinical Rheumatology
|June 23, 2015
PubMed
Summary

Infective arthritis, caused by microbes like bacteria and viruses, is increasingly diagnosed with advanced techniques. Understanding causative agents and diagnostic accuracy improves treatment for infectious and inflammatory joint diseases.

Keywords:
ChikungunyaPolymerase chain reactionReactive arthritisSeptic arthritisSynovial fluidViral arthritis

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Area of Science:

  • Rheumatology
  • Infectious Diseases
  • Microbiology

Background:

  • Arthritis can stem from bacterial, viral, fungal, or parasitic infections, presenting acutely or chronically.
  • Infective arthritis encompasses septic, reactive, and inflammatory types.
  • Advances in diagnostics have improved outcomes for infectious arthritis.

Purpose of the Study:

  • To review causative agents of infective arthritis.
  • To outline diagnostic approaches and their statistical accuracy.
  • To highlight emerging viral roles in arthritis pathogenesis.

Main Methods:

  • Discussion of various causative agents.
  • Emphasis on diagnostic strategies for different arthritis types.
  • Inclusion of newer methods like polymerase chain reaction (PCR).

Main Results:

  • Improved diagnostic techniques enhance treatment for infective arthritis.
  • Emerging arthritogenic viruses are altering infection-related arthritis epidemiology.
  • Viral involvement in chronic inflammatory arthritides like rheumatoid arthritis is recognized.

Conclusions:

  • Accurate diagnosis of infective arthritis relies on understanding causative agents and utilizing advanced tests.
  • Polymerase chain reaction (PCR) and other nucleic acid amplification methods offer improved detection.
  • Awareness of diagnostic pitfalls is crucial for effective interpretation and patient management.