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Updated: Apr 9, 2026

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Controlled Delivery of Human Cells by Temperature Responsive Microcapsules.

W C Mak1,2, K Olesen3, P Sivlér4

  • 1Integrative Regenerative Medicine Centre, Department of Clinical and Experimental Medicine, Linköping University, SE58185, Linköping, Sweden. mamak@ifm.liu.se.

Journal of Functional Biomaterials
|June 23, 2015
PubMed

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Summary

Researchers developed temperature-responsive microcapsules for cell therapy, improving cell survival and enabling controlled release. This innovation addresses challenges in regenerative medicine by protecting therapeutic cells in adverse environments.

Area of Science:

  • Regenerative Medicine
  • Biomaterials Science
  • Cell Biology

Background:

  • Cell therapy holds promise for regenerative medicine but faces challenges like cell loss due to anoikis and harsh tissue environments.
  • Encapsulation strategies are being explored to enhance therapeutic cell viability and efficacy post-transplantation.

Purpose of the Study:

  • To develop a facile, high-throughput method for creating temperature-responsive microcapsules for cell delivery and controlled release.
  • To investigate the use of composite microcapsules made from agarose, gelatin, and fibrinogen for enhanced cell viability and release.

Main Methods:

  • Fabrication of temperature-responsive microcapsules using a combination of agarose, gelatin, and fibrinogen.
  • Encapsulation and controlled release studies using human fibroblasts and human umbilical vein endothelial cells (HUVECs).
Keywords:
cell deliverycell encapsulationhuman fibroblasthuman umbilical vein endothelial cellshydrogelmicrocapsulestemperature responsive

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  • Verification of capsule destabilization and cell release triggered by phase transition temperatures.

    • Main Results:

    • Successful development of a high-throughput method for creating composite, temperature-responsive microcapsules.
    • Demonstrated efficient encapsulation and controlled release of both human fibroblasts and HUVECs.
    • Confirmed that differing phase transition temperatures of agarose and gelatin facilitate capsule destabilization for cell release.

    Conclusions:

    • Composite, temperature-responsive microcapsules offer a promising approach for protecting and controlling the release of therapeutic cells.
    • The developed microcapsule system demonstrates potential for improving cell therapy outcomes in regenerative medicine.
    • Further optimization of microcapsule composition and cell loading is required for clinical translation.