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Related Concept Videos

Pulmonary Hypertension: Classification and Pathogenesis01:30

Pulmonary Hypertension: Classification and Pathogenesis

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Pulmonary hypertension (PH) is a severe health condition in which the mean pulmonary arterial pressure increases to 25 mmHg or more, even when the body is at rest. This high pressure in the blood vessels that transport blood from the heart to the lungs can cause various symptoms, including shortness of breath, can lead to right heart failure, and significantly affect the overall quality of life.
There are various classifications for PH, each relating to different underlying causes and also...
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Mitral Regurgitation I: Introduction01:20

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Mitral regurgitation is characterized by the backward circulation of blood from the left ventricle to the left atrium during systole, a phase of the cardiac cycle when the heart contracts and pumps blood out of the chambers. This abnormal flow occurs primarily due to the dysfunction of the mitral valve or its supporting structures, which include the mitral leaflets, chordae tendineae, annulus, and papillary muscles.Etiology and Mechanisms:Primary Mitral Regurgitation: This type arises from...
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Heart Failure III: Clinical Manifestations01:26

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Heart failure (HF) manifests primarily as dyspnea, fatigue, and fluid retention, resulting in peripheral and pulmonary edema. Symptoms may vary depending on which ventricle is more affected, left or right.Left-Sided Heart FailureAlso known as left ventricular failure, this condition results from the left ventricle's inability to fill or eject sufficient blood into the systemic circulation. It leads to pulmonary congestion, which occurs when the left ventricle fails to eject blood effectively...
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Mitral Stenosis I: Introduction01:22

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Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
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Pathophysiology of Heart Failure01:17

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Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
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Heart Failure I: Introduction01:27

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Heart failure refers to a clinical syndrome caused by structural or functional cardiac disorders that prevent the heart from pumping an adequate amount of blood to meet the body's metabolic needs. This condition often arises from myocardial infarction or ischemia, leading to decreased cardiac output, reduced tissue perfusion, impaired gas exchange, fluid volume imbalance, and decreased functional ability.Heart failure can result from disruptions in the mechanisms that regulate cardiac output...
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Related Experiment Video

Updated: Apr 9, 2026

A Model of Reverse Vascular Remodeling in Pulmonary Hypertension Due to Left Heart Disease by Aortic Debanding in Rats
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Right and left heart dysfunction predict mortality in pulmonary hypertension.

Michael Y Henein1,2, Christer Grönlund3, Erik Tossavainen1

  • 1Department of Cardiology, Heart Centre, Umeå University, Umeå, Sweden.

Clinical Physiology and Functional Imaging
|June 23, 2015
PubMed
Summary

In precapillary pulmonary hypertension (PH), both left and right heart dysfunction predict mortality. Key indicators include right atrial pressure, tricuspid regurgitation severity, and left ventricular filling time.

Keywords:
Doppler echocardiographydiastolic functionleft heart functionprecapillary pulmonary hypertensionright heart function

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Area of Science:

  • Cardiology
  • Pulmonary Hypertension Research
  • Echocardiography

Background:

  • Right heart dysfunction is a known predictor of adverse outcomes in pulmonary hypertension (PH).
  • The role of left heart function in precapillary PH prognosis remains incompletely understood.
  • Identifying comprehensive predictors is crucial for managing precapillary PH.

Purpose of the Study:

  • To identify mortality predictors in precapillary PH.
  • To assess the combined role of right and left heart function in predicting outcomes.
  • To utilize advanced echocardiographic techniques for detailed cardiac assessment.

Main Methods:

  • Study included 34 patients with precapillary PH.
  • Detailed Doppler and speckle-tracking echocardiography assessed right and left heart function.
  • Patients were followed for up to 8 years to determine mortality.

Main Results:

  • Worse left ventricular filling time, pulmonary artery acceleration time, right atrial pressure (RAP), and tricuspid regurgitation (TR) severity were observed in deceased patients.
  • Right ventricular global longitudinal strain (RV GLS), RAP, LV filling time, and TR severity were the most accurate mortality predictors.
  • These predictors, reflecting both left and right heart dysfunction, showed the largest AUC (>0.65) and highest mortality risk.

Conclusions:

  • Mortality in precapillary PH is strongly predicted by indicators of both left and right heart dysfunction.
  • Atrial structure and function disturbances are also implicated in mortality risk.
  • Further validation in larger cohorts is needed to confirm these findings and their interaction patterns.