[Kidney function in patients with hydronephrosis complicated by pyelonephritis and nephrolithiasis]

Area of Science:

• Nephrology
• Urology
• Renal Physiology

Background:

• Hydronephrosis, characterized by kidney swelling, can impair renal function.
• Understanding functional changes is crucial for managing hydronephrosis, especially in non-obstructive, non-infectious cases.

Purpose of the Study:

• To investigate renal plasma flow and glomerular filtration in hydronephrosis patients.
• To analyze osmoregulating and ion-regulating renal function in hydronephrosis.
• To identify functional changes in hydronephrosis without infection, pyelonephritis, or nephrolithiasis.

Main Methods:

• Studied 382 patients diagnosed with hydronephrosis.
• Assessed renal plasma flow and glomerular filtration rates.
• Evaluated indices of osmoregulating and ion-regulating renal function.

Main Results:

• Documented specific regularities of functional changes in renal plasma flow and glomerular filtration.
• Observed alterations in osmoregulating and ion-regulating renal function.
• Characterized these changes in unilateral, bilateral, and single-kidney hydronephrosis cases, excluding infection and stones.

Conclusions:

• Hydronephrosis leads to distinct changes in renal plasma flow and glomerular filtration.
• Osmoregulating and ion-regulating functions are significantly affected by hydronephrosis.
• These functional alterations occur even in the absence of infection, pyelonephritis, or nephrolithiasis.