[Allergic complications in patients with rheumatism]

The frequency and character of drug allergy was evaluated in 200 patients with rheumatism. Drug allergy was revealed in 60% of patients, in 62.5% of them to two and more drugs. Allergy was frequent in women and was influenced by concomitant lesions of the digestive and biliary organs, genetic factors (familial predisposition), presence of nondrug reactions. Most frequently allergic complications were observed due to use of antibiotics (37.5%), in particular, of the penicillin group; nonsteroid anti-inflammatory medicinal agents (13.5%) of all patients), primarily, the employment of pyrazolon drugs.