[Modelling of a combined immunodeficiency state by splenectomy and alloimmunization with lymph node antigens]

Autoimmune pathology was modelled in splenectomized animals by allosensitization with lymphoid tissue in association with Freund's adjuvant. It was found that splenectomy in guinea pigs produces stable disorders of homeostasis and morphological picture of the heart, liver, inguinal lymph nodes as well as a imbalance of the autoregulation mechanisms. The authors obtained an experimental model of autoimmune pathology that may be used for investigation of the pathogenesis of these states as well as for developing methods of corrective therapy.