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Vinayaraj Ozhukil Kollath1,2,3, Freya Van den Broeck4, Krisztina Fehér4

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Functionalizing hydroxyapatite (HA) nanoparticles with specific molecules alters their protein adsorption. This research optimizes HA carriers for enhanced protein delivery in biotechnological applications.

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Area of Science:

  • Biomaterials science
  • Nanotechnology
  • Surface chemistry

Background:

  • Biocompatible inorganic nano- and microcarriers are promising for protein delivery.
  • Surface functionalization is key to controlling protein adsorption capacity.

Purpose of the Study:

  • To investigate how nanoscale linker molecules affect the protein adsorption capacity of hydroxyapatite (HA) powder.
  • To explore the influence of surface modifications on bovine serum albumin adsorption onto HA.

Main Methods:

  • Surface functionalization of HA powder with lysine, arginine, and phosphoserine.
  • Analysis of protein adsorption using bovine serum albumin as a model protein.
  • Characterization of surface interactions using NMR spectroscopy, zeta-potential, XPS, and TGA.
  • Correlation with Langmuir and Freundlich isotherm models.

Main Results:

  • Lysine and arginine increased protein adsorption capacity.
  • Phosphoserine decreased protein adsorption capacity.
  • Surface functionalization effectively modulated HA's electrostatic properties and protein binding.

Conclusions:

  • Surface functionalization of hydroxyapatite with specific linker molecules offers a controllable method for tuning protein adsorption.
  • This approach has significant implications for designing advanced biomaterial carriers for targeted protein delivery in biotechnology.