[Agranulocytosis related to fluindione: A case report]
S Ngo1, Y Benhamou1, G Armengol1
1Département de médecine interne, CHU Rouen, 1, rue de Germont, 76031 Rouen cedex, France.
Introduction:
While in most countries warfarin is the preferred anti-vitamin K, fluindione, a molecule with a prolonged half-life remains largely prescribed in France. Some of its side effects, including immuno-allergic complications, remain poorly understood.
Case Report:
A 77-year-old woman presented with a febrile severe neutropenia of immunoallergic mechanism with a favourable outcome associated with fluindione, introduced 25 days earlier for the treatment of atrial fibrillation.
Conclusion:
This rare side effect is a reminder of the importance of biological monitoring in the first weeks following the introduction of fluindione and key diagnostic elements and therapeutic aspects of iatrogenic agranulocytosis.
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