Related Experiment Video
Updated: Jan 31, 2026

Single-Molecule Fluorescence Visualization of DNA Polymerase Dynamics at G-Quadruplexes
Published on: April 4, 2025
A Personal History of Quadruplex-Small Molecule Targeting
1UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London, WC1N 1AX, UK.
Abstract:
The story behind some of the early studies in the laboratory of Stephen Neidle on quadruplex-binding small molecules and the structural studies on quadruplexes and their complexes is presented and discussed in the context of his earlier work on drug-DNA interactions. More recent studies and future directions in the rational design of small molecules targeting telomeric and gene promoter quadruplexes are also described.
Related Concept Videos
Life Histories
Personal Identity
Nursing Assessment of the Genitourinary System I: Health History
History of Microbiology
What is Evolutionary History?
Molecules and Compounds

