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Comprehensive translational control of tyrosine kinase expression by upstream open reading frames

K Wethmar1,2, J Schulz1, E M Muro3,4

  • 1Department of Cell Differentiation and Tumorigenesis, Max-Delbrueck-Center for Molecular Medicine, Berlin, Germany.

Oncogene
|June 23, 2015
PubMed
Summary

Upstream open reading frames (uORFs) regulate gene expression by controlling translation initiation. Disruptions in these uORFs can lead to increased proto-oncogene translation, potentially contributing to cancer development.

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