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Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response
Published on: September 15, 2017
Associations of sedentary time patterns and TV viewing time with inflammatory and endothelial function biomarkers in
L Gabel1,2, N D Ridgers3, P A Della Gatta3
1Experimental Medicine Program, Faculty of Medicine & Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada.
Insights
Increased TV viewing in children is linked to higher inflammation markers and endothelial dysfunction. Shorter sedentary bouts also showed a trend toward increased inflammation, suggesting potential long-term health risks.
Area of Science:
- Pediatric health
- Biomarkers of inflammation
- Endothelial function
Background:
- Sedentary behavior and TV viewing are prevalent in children.
- Understanding their impact on health is crucial for early intervention.
Purpose of the Study:
- To investigate the association between TV viewing time and sedentary time with inflammatory and endothelial function biomarkers in children.
- To explore how different patterns of sedentary time accumulation relate to these biomarkers.
Main Methods:
- Cross-sectional analysis of 164 children aged 7-10 years.
- TV viewing assessed by parental report; sedentary time by accelerometry.
- Measured biomarkers included C-reactive protein (CRP), soluble intercellular adhesion molecule 1 (sICAM-1), and soluble vascular adhesion molecule 1 (sVCAM-1), among others.
Main Results:
- Each additional hour of TV viewing per week was associated with increased CRP and sVCAM-1 levels.
- Sedentary time in 5-10 minute bouts showed a positive association with CRP, though this was attenuated after dietary adjustments.
Conclusions:
- TV viewing is unfavorably associated with inflammation and endothelial dysfunction markers in children.
- Further longitudinal research is needed to confirm the impact of sedentary time accumulation on early-life health.
Objective:
Investigate associations of TV viewing time and accelerometry-derived sedentary time with inflammatory and endothelial function biomarkers in children.
Methods:
Cross-sectional analysis of 164 7-10-year-old children. TV viewing time was assessed by parental proxy report and total and patterns of sedentary time accumulation (e.g. prolonged bouts) were assessed by accelerometry. C-reactive protein (CRP), homeostasis model assessment of insulin resistance, interleukin-2, -6, -8, -10, tumour necrosis factor alpha, adiponectin, resistin, brain-derived neurotrophic factor, soluble intercellular and vascular adhesion molecule 1, plasminogen activator inhibitor 1 and soluble E-selectin were assessed. Generalised linear models assessed the associations of TV viewing and sedentary time with biomarkers, adjusting for sex, waist circumference, moderate- to vigorous-intensity physical activity and diet density.
Results:
Each additional h week(-1) of TV viewing was associated with 4.4% (95% CI: 2.1, 6.7) greater CRP and 0.6% (0.2, 1.0) greater sVCAM-1 in the fully adjusted model. The association between frequency and duration of 5-10 min bouts of sedentary time and CRP was positive after adjustment for sex and waist circumference but attenuated after adjustment for diet density.
Conclusions:
This study suggests that TV viewing was unfavourably associated with several markers of inflammation and endothelial dysfunction. The detrimental association between 5 and 10 min bouts of sedentary time and CRP approached significance, suggesting that further research with a stronger study design (longitudinal and/or experimental) is needed to better understand how the accumulation of sedentary time early in life may influence short and longer term health.
