Related Experiment Video
Updated: Apr 8, 2026

A Porcine Heterotopic Heart Transplantation Protocol for Delivery of Therapeutics to a Cardiac Allograft
Published on: February 14, 2022
Advances in the understanding and management of heart transplantation
Dhssraj Singh1, David O Taylor1
1Department of Cardiovascular Medicine, Heart and Vascular Institute Cleveland Clinic, 9500 Euclid Avenue, Cleveland, Ohio 44195 USA.
Abstract:
Cardiac transplantation represents one of the great triumphs in modern medicine and remains the cornerstone in the treatment of advanced heart failure. In this review, we contextualize pivotal developments in our understanding and management of cardiac transplant immunology, histopathology, rejection surveillance, drug development and surgery. We also discuss current limitations in their application and the impact of the left ventricular assist devices in bridging this gap.
Related Concept Videos
Cardiomyopathy V: Interprofessional Care
Kidney Transplant I: Introduction
Tissue Transplantation
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
Heart Failure VI: Adjunct Therapies

