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Normothermic Machine Perfusion of Rat Kidneys for Transplantation
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[Physiologic performance of clinically non-functioning kidney transplants].

J Groth1, V Strobelt, M Bursche

  • 1Abteilung für Experimentelle Organtransplantation, Urologischen Klinik des Bereiches Medizin (Charité) der Humboldt-Universität zu Berlin.

Zeitschrift Fur Urologie Und Nephrologie
|October 1, 1989
PubMed
Summary
This summary is machine-generated.

Many kidney allografts initially deemed non-functional show some excretion capacity. Early, unidentified rejection may cause irreversible graft loss, impacting transplant outcomes.

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Area of Science:

  • Nephrology
  • Transplantation immunology

Context:

  • Evaluation of kidney allografts experiencing non-function after transplantation.
  • Assessment of dialysis in managing non-functional kidney transplants.

Purpose:

  • To examine the excretion capacity of kidney allografts initially considered non-functional.
  • To determine the actual functional status of dialyzed kidney transplants.

Summary:

  • Out of 24 examined kidney allografts treated with dialysis for non-function, only 4 (16.7%) were completely non-functional.
  • The majority of allografts demonstrated improved excretion capacity before eventual irreversible graft failure.
  • Unidentified graft rejection is proposed as a potential cause for the observed decline in function.

Impact:

  • Highlights the potential for residual function in non-functional kidney allografts.
  • Suggests the need for improved methods to detect and manage early, unidentified graft rejection.
  • Informs clinical practice regarding the assessment and management of kidney transplant recipients.