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Related Experiment Videos

Treatment with locally applied mitoxantrone.

K Kuhn1, H Purea, J Selbach

  • 1Medizinischen Klinik II für Hämatologie, Onkologie und Immunologle, St. Johannes-Hospital, Duisburg, FRG.

Acta Medica Austriaca
|January 1, 1989
PubMed
Summary

Intracavitary mitoxantrone showed promise in treating malignant effusions and peritoneal carcinosis. This approach led to complete or partial remission in a significant number of patients with these advanced cancers.

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Area of Science:

  • Oncology
  • Pharmacology

Background:

  • Malignant effusions and peritoneal carcinosis are advanced stages of cancer.
  • Intracavitary chemotherapy offers a targeted approach to localized cancer spread.

Purpose of the Study:

  • To evaluate the efficacy of intracavitary mitoxantrone in patients with malignant pleural effusion, pericardial effusion, and peritoneal carcinosis.

Main Methods:

  • Mitoxantrone was administered intracavitary (intraperitoneally, intrapleurally, or intrapericardially) to 30 patients.
  • Response was assessed based on complete and partial remission rates.

Main Results:

  • In malignant pleural effusion (13 patients): 5 complete and 3 partial remissions.
  • In pericardial effusion (2 patients): 2 complete remissions.

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  • In peritoneal carcinosis (16 patients): 4 complete and 3 partial remissions.

    • Conclusions:

    • Intracavitary mitoxantrone demonstrates significant efficacy in managing malignant effusions and peritoneal carcinosis.
    • This administration route provides a viable treatment option for localized cancer recurrence.