Origin of the ultimobranchial body and its colonizing cells in human embryos

The early development of the ultimobranchial body and its colonizing cells was studied in human embryos (O'Rahilly's stages 14 and 15). In our studies we have obtained evidence that permits us to propose a new hypothesis on the origin of both the ultimobranchial body and its colonizing cells. Based on our interpretation of the morphogenetic features in human development, we think that the ultimobranchial body derives from the fifth endodermal pharyngeal pouch, which is colonized, from O'Rahilly's stage 14 on, by cellular material of ectodermal placodial nature that originates in the most caudal portion of the epicardiac branchial placode.