A novel spectrophotometry method accurately determines mixed drug components without separation. This simple, rapid technique offers satisfactory recovery and precision for pharmaceutical analysis.
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Accurate quantification of active pharmaceutical ingredients in complex mixtures is crucial for quality control.
Traditional methods often require laborious separation steps, increasing analysis time and cost.
Developing rapid, non-separation techniques is a key objective in pharmaceutical analysis.
Purpose:
To introduce and validate a new multiwavelength absorbance ratio difference spectrophotometry method.
To demonstrate the application of this method for the simultaneous determination of diphenhydramine hydrochloride and ephedrine hydrochloride, and amidopyrine and caffeine.
To assess the method's accuracy, precision, and efficiency in analyzing mixed pharmaceutical components.
Summary:
A novel multiwavelength absorbance ratio difference spectrophotometry method was developed for simultaneous analysis of binary mixtures.
The method was successfully applied to quantify diphenhydramine hydrochloride, ephedrine hydrochloride, amidopyrine, and caffeine without prior separation.
Excellent mean recoveries (94.86-101.0%) and low coefficients of variation (0.56-1.0%) were achieved, demonstrating high precision and accuracy.
Impact:
Provides a simple, rapid, and accurate analytical tool for pharmaceutical quality control.
Reduces the need for complex separation procedures, saving time and resources.
Facilitates the efficient determination of multiple drug components in pharmaceutical formulations.
