Related Experiment Video
Updated: Apr 8, 2026
In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography
Published on: February 16, 2016
Prediction of myocardial tissue loss by quantitative densitometric myocardial blush parameters following ST-elevation
V Sasi1, H Gavallér, A Kalapos
1Division of Invasive Cardiology, Department of Cardiology, Medical Faculty, Albert Szent-Györgyi Clinical Center, University of Szeged , Szeged , Hungary.
Insights
Myocardial perfusion assessed by videodensitometry after ST-elevation myocardial infarction (STEMI) can predict late tissue loss. This quantitative method offers a feasible approach for assessing prognosis after revascularization therapy.
Area of Science:
- Cardiology
- Medical Imaging
- Biomedical Engineering
Background:
- Tissue-level myocardial perfusion is a critical prognostic factor in acute ST-elevation myocardial infarction (STEMI) patients post-recanalization.
- Assessing perfusion directly after revascularization is crucial for predicting long-term outcomes.
Purpose of the Study:
- To investigate the relationship between videodensitometric myocardial perfusion parameters from coronary angiography and magnetic resonance imaging (MRI)-derived myocardial tissue loss late after STEMI.
- To evaluate the predictive value of G(max)/T(max) for myocardial tissue loss.
Main Methods:
- The study included 29 STEMI patients undergoing successful recanalization therapy.
- Videodensitometric parameter G(max)/T(max) was calculated from coronary angiograms.
- Myocardial Loss Index (MLI) was assessed using cardiac MRI at approximately 376 days post-PCI.
Main Results:
- Significant correlations were found between MLI and G(max) (r = 0.36, p = 0.05) and G(max)/T(max) (r = 0.40, p = 0.03).
- Receiver operating characteristic curve analysis indicated that G(max)/T(max) < 2.17 predicted MLI values of 0.3-0.6 with good sensitivity and specificity.
- G(max)/T(max) < 3.25 showed prognostic value for predicting MLI = 0.7.
Conclusions:
- Quantitative measurement of myocardial tissue-level perfusion using videodensitometry is feasible.
- This method serves as a valuable predictor of myocardial tissue loss following STEMI and revascularization.
Unlabelled:
Tissue level myocardial perfusion is one of the most important prognostic factors after successful recanalisation of the occluded coronary artery in patients suffering acute ST elevation myocardial infarction (STEMI). The primary objective of the present study was to examine the relationship between videodensitometric myocardial perfusion parameters as assessed on coronary angiograms directly following successful recanalization therapy and magnetic resonance imaging (MRI)-derived myocardial tissue loss late after STEMI. The study comprised 29 STEMI patients. Videodensitometric parameter G(max)/T(max) was calculated to characterize myocardial perfusion, derived from the plateau of grey-level intensity (G(max)), divided by the time-to-peak intensity (Tmax). Myocardial loss index (MLI) was assessed by cardiac MRI following 376 ± 254 days after PCI.
Results:
Significant correlations could be demonstrated between MLI and G(max) (r = 0.36, p = 0.05) and G(max)/T(max) (r = 0.40, p = 0.03) using vessel masking. Using receiver operating characteristic curve analysis, G(max)/T(max) < 2.17 predicted best MLI = 0.3, 0.4, 0.5 and 0.6 with good sensitivity and specificity data, while G(max)/T(max) < 3.25 proved to have a prognostic role in the prediction of MLI = 0.7.
Conclusions:
Selective myocardial tissue level perfusion quantitative measurement method is feasible and can serve as a good predictor of myocardial tissue loss following STEMI and revascularization therapy.
Related Concept Videos
01:30Acute Coronary Syndrome III: Diagnostic Studies
01:27Myocarditis II: Clinical Features and Diagnostic Tests
01:20Blood Studies for Cardiovascular System I: Cardiac Biomarkers
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...