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Childhood asthma biomarkers: present knowledge and future steps.
Laura Moschino1, Stefania Zanconato1, Sara Bozzetto1
1Department of Women's and Children's Health, University of Padova, Padova Italy.
Paediatric Respiratory Reviews
|June 24, 2015
Summary
Identifying objective asthma biomarkers is crucial for childhood asthma diagnosis and personalized treatment. Exhaled biomarkers like nitric oxide and breath condensate molecules offer promising non-invasive monitoring of airway inflammation.
Area of Science:
- Pediatric Pulmonology
- Biomarker Discovery
- Respiratory Medicine
Background:
- Asthma is the most common chronic respiratory disease in children.
- Current diagnosis relies on symptoms and airflow limitation, which may not reflect underlying airway inflammation.
- Diverse pathogenetic mechanisms contribute to asthma's broad clinical spectrum.
Purpose of the Study:
- To highlight existing knowledge on asthma biomarkers, focusing on exhaled biomarkers.
- To emphasize the clinical utility of objective biomarkers for diagnosis, phenotyping, and personalized therapy.
- To underscore the importance of non-invasive methods for monitoring childhood asthma inflammation.
Main Methods:
- Review of existing literature on asthma biomarkers.
- Focus on exhaled biomarkers, including exhaled nitric oxide (FE(NO)) and molecules in exhaled breath condensate (EBC).
- Exploration of novel metabolomic approaches applied to exhaled biomarkers.
Main Results:
- Exhaled biomarkers show promise for non-invasive monitoring of airway inflammation in childhood asthma.
- Metabolomic analysis of exhaled biomarkers is an emerging area with encouraging results.
- Objective biomarkers can aid in refining asthma diagnosis and management.
Conclusions:
- Objective asthma biomarkers are essential for accurate diagnosis and personalized treatment strategies.
- Non-invasive exhaled biomarkers offer a valuable tool for monitoring pediatric asthma.
- Further research into exhaled biomarkers, including metabolomics, is warranted for improved asthma care.
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